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| BORIS-ARTO | Дата: Воскресенье, 18.03.2007, 03:23 | Сообщение # 1 |
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| fmyykjw | Дата: Вторник, 19.01.2016, 22:15 | Сообщение # 95 |
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| Moxidectin (Milbemycin B[1 - ) kills parasites, so is acclimated to on the mitigation and control of heartworm and intestinal worms, and can be create in treatments prescribed to go to animals such as dogs, cats, horses, steers and sheep. Application methods towards moxidectin change before treatment, and register vocalized, timely, and injectable solutions. Cydectin Flow On is a trade choose after a formulation for urgency on cows and red deer.
Moxidectin is a semisynthetic derivative of nemadectin [2 - which is produced past fermentation next to Streptomyces cyano-griseus. This Streptomyces species was discovered in a defile sampler from Australia in the past due 1980s at ease by means of an agronomist working destined for the American Cyanamid company.
Moxidectin treats and controls some of the most mean internal and outward parasites by selectively binding to parasites’ glutamate-gated chloride ion channels. These channels are mandatory to the chore of invertebrate fortitude and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and termination of the parasite.
Studies of moxidectin show the side effects remodel at near animal and may be affected beside the result’s formulation, assiduity method and dosage. The products are most often recommended about a veterinarian to make sure counterbalance avail oneself of and application. Herding dogs may be avermectin-sensitive, but avermectin-sensitive dogs can tolerate paragon doses seeking heartworm prevention. Moxidectin is manifestly all right for collie breeds. As a heartworm preventative, moxidectin can be injected in a minute every six months call of the make name Proheart6, or every 12 months lower than drunk the brand eminence Proheart SR 12.
Moxidectin is the source of a effort to assess its suitability, as an alternate to ivermectin, to doctor onchocerciasis in humans.[3 -
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| tcsindustryz | Дата: Пятница, 01.07.2016, 13:09 | Сообщение # 97 |
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Группа: Гости
| Docetaxel (as generic or under the job eminence Taxotere) is a clinically traditional anti-mitotic chemotherapy medication (medication which interferes with cubicle compartmentation). It is used mainly payment the treatment of heart, ovarian, prostate, and non-small chamber lung cancer.[1 - [2 - [3 - Docetaxel has an FDA approved allege as a service to treatment of patients who possess locally advanced, or metastatic mamma or non small-cell lung cancer who procure undergone anthracycline-based chemotherapy and failed to stop cancer advance or relapsed[4 - and a European subscribe to payment use in hormone-refractory prostate cancer.[5 -
According to a 2005 article in the annual Drugs, docetaxel administered as a one-hour infusion every three weeks generally in excess of a ten return track, docetaxel is considered as or more compelling than doxorubicin, paclitaxel and fluorouracil as a cytotoxic agent.[1 - Respect the effectiveness of docetaxel versus paclitaxel and other taxanes is quiescent controversial. Diverse more current articles father set up "no sign that regimens containing docetaxel cry quits greater benefits than those including paclitaxel."[6 - Additionally, the optimal scheduling of docetaxel and other taxanes remains unconfirmed. A three-week charge schedule used to be and is still considered efficient but chic studies are indicating a weekly plan influence be better. A 2010 article in Current Clinical Pharmacology states, "weekly charge has emerged as the optimal schedule." Docetaxel is marketed worldwide comprised in the identify Taxotere during Sanofi-Aventis.[7 - Annual sales in 2010 were Euro 2.122 billion ($US 3.1 billion). The patent expired in 2010.[citation
Stamp
Docetaxel is of the chemotherapy knock out class; taxane, and is a semi-synthetic analogue of paclitaxel (Taxol), an draw forth from the bark of the rare Pacific yew tree Taxus brevifolia.[2 - Due to dearth of paclitaxel, vast scrutiny was carried peripheral exhausted primary to the formulation of docetaxel – an esterified yield of 10-deacetyl baccatin III, which is extracted from the renewable and agreeably available European yew tree.
Docetaxel differs from paclitaxel at two positions in its chemical structure. It has a hydroxyl functional group on carbon 10, whereas paclitaxel has an acetate ester, and a tert-butyl carbamate ester exists on the phenylpropionate side string as an alternative of the benzyl amide in paclitaxel. The carbon 10 functional organize mutation causes docetaxel to be more sea water soluble than paclitaxel.[2 -
Formulations and compositions
Docetaxel is a snowy powder and is the active ingredient convenient in 20 mg and 80 mg Taxotere single-dose vials of concentrated anhydrous docetaxel in polysorbate 80.[2 - [8 - The figuring out is a clear brown-yellow containing 40 mg docetaxel and 1040 mg polysorbate 80 per mL.[8 - 20 mg Taxotere is distributed in a blister carton containing harmonious single-dose vial of Taxotere (docetaxel) preparation in 0.5 mL disinfected pyrogen-free anhydrous polysorbate 80, and a only amount Taxotere solvent vial containing 1.5 mL 13% ethanol in saline to be combined and diluted in a 250 mL infusion bag containing 0.9% sodium chloride or 5% glucose in the interest administration.[8 - 80 mg Taxotere is supplied identically but with 2.0 mL polysorbate 80 and 6.0 mL 13% ethanol in saline. The docetaxel and profitable vials are combined to bestow a unravelling of 10 mg/mL and the required measure is haggard from this solution. Vials suffer with an overfill to balance in compensation solvent loss during preparation, foaming, adhesion to vial walls and the numb volume. 20 mg vials may be stored for 24 months below 25 °C away from understanding and 80 mg vials since 26 months in the nevertheless conditions.[8 -
Recently Sanofi has got approval in behalf of one-vial formulation.[citation needed - With this one-vial formulation, the preparation of the infusion infusion is simplified alongside eliminating the before dilution step. The two-vial and one-vial formulations contain the unchanged dose pith, docetaxel trihydrate, and the uniform excipients (ethanol, polysorbate 80 and citric acid). The one-vial formulation is administered as an aqueous intravenous solution that contains the unchanging numb burden in the unchanged concentration as the already approved two-vial formulation. The unmodified level, status, and measure of polysorbate 80 are proximate in the infusion elucidation of both formulations. The however unlikeness between these two formulations is the quantity of ethanol.
From http://www.tcsindustry.com - TCS INDUSTRY LTD
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| famuyiyaok | Дата: Пятница, 09.09.2016, 18:53 | Сообщение # 98 |
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Группа: Гости
| Gallic acid is a trihydroxybenzoic acid, a type of phenolic acid, a type of organic acid, also known as 3,4,5-trihydroxybenzoic acid, found in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants.<> - The chemical formula is C6H2(OH)3COOH. Gallic acid is found both free and as part of hydrolyzable tannins. The gallic acid groups are usually bonded to form dimers such as ellagic acid. Hydrolysable tannins break down on hydrolysis to give gallic acid and glucose or ellagic acid and glucose, known as gallotannins and ellagitannins respectively.
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| fmyykjr | Дата: Воскресенье, 18.09.2016, 13:10 | Сообщение # 99 |
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Группа: Гости
| Gallic acid is a trihydroxybenzoic acid, a type of phenolic acid, a type of organic acid, also known as 3,4,5-trihydroxybenzoic acid, found in gallnuts, sumac, witch hazel, tea leaves, oak bark, and other plants.<> - The chemical formula is C6H2(OH)3COOH. Gallic acid is found both free and as part of hydrolyzable tannins. The gallic acid groups are usually bonded to form dimers such as ellagic acid. Hydrolysable tannins break down on hydrolysis to give gallic acid and glucose or ellagic acid and glucose, known as gallotannins and ellagitannins respectively.
From http://www.fmyykj.com - suzhou pharmaceutical technology co.,ltd.
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| JimmyveW | Дата: Вторник, 17.01.2017, 03:26 | Сообщение # 100 |
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